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E-Liquid Stability: Why Your Vape Juice Changes Over Time—and Whether It Matters

E-liquid degrades over time—nicotine oxidizes, flavor compounds react, and the liquid darkens. The degradation can affect taste, satisfaction, and potentially safety. E-liquid stability is an understudied dimension of vaping science.

Leave a bottle of e-liquid in a hot car for a week, and it will darken, change flavor, and potentially produce higher levels of degradation products. **E-liquid stability is affected by temperature, light, oxygen, and time. The degradation products—nicotine oxide, reactive carbonyls—are different from the compounds in fresh e-liquid, and their inhalation toxicology is largely unstudied. The e-liquid in your device is not a stable chemical mixture. It's evolving—and the evolution may affect what you inhale.**

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